Arginine Deiminase Inhibit Argininosuccinate Synthetase-Deficient PANC-1 Cell Invasion Via Suppression of Pi3K/Akt/Nf-κB Signal
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چکیده
منابع مشابه
Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines
Gastric cancer metastasis remains a major cause of cancer-related deaths. There is an urgent need to develop new therapeutic approaches targeting metastatic gastric cancer. Argininosuccinate synthetase 1 (ASS1) expression is increased in gastric cancer. We detected the protein expression of ASS1 in human gastric cancer cell lines (AGS, NCI-N87, and MKN45) and in murine gastric cancer cell lines...
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I f a universality of biological phenomena exists, it would be expected that the control of enzyme levels in mammalian tissues conform, at least in part, to the classic induction-repression phenomenon as observed in numerous bacterial systems (2). However, to date, distinct repression phenomena in mammalian systems have been observed only in the case of glycine transamidinase in chicken (3, 4) ...
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It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not normal cells. This concept was translated into clinical trial and responses were seen. However, induction of ASS expression does occur w...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2013
ISSN: 0923-7534
DOI: 10.1093/annonc/mdt203.46